研究成果 Refereed Papers (*: 通訊作者)
近年內主要研究成果 (*:通訊作者)
Wang PK, Cao J, Wang H, Liang L, Zhang J, Lutz BM, Shieh KR, Bekker A, Tao YX: Short-term sleep disturbance-induced stress does not affect basal pain perception, but does delay postsurgical pain recovery. Journal of Pain. In Press.
Yang SC, Chen CL, Yi CH, Liu TT, Shieh KR*: Changes in gene expression patterns of circadian-clock, transient receptor potential vanilloid-1 and nerve growth factor in inflamed human esophagus. Scientific Reports. 5: 13602, 2015.
Tseng HL, Yang SC, Shieh KR*: Hepatic circadian-clock system altered by insulin resistance, diabetes and insulin sensitizer in mice. PLOS One. 10: e0120380, 2015.
Shieh KR, Yang SC, Tseng HL, Yi CH, Liu TT, Chen CL: Evidence for up-regulation of purinergic receptor genes associating with TRPV1 receptors and neurotrophic factors in the inflamed human esophagus. Current Molecular Medicine 14: 1205-1214, 2014.
Yang SC, Tseng HL, Shieh KR*: Circadian-clock system in mouse liver affected by insulin resistance. Chronobiology International 30: 796-810, 2013.
Shieh KR, Yi CH, Liu TT, Tseng HL, Ho HC, Hsieh HT, Chen CL: Evidence for neurotrophic factors associating with TRPV1 gene expression in the inflamed human esophagus. Neurogastroenterology and Motility 9: 971-e252, 2010.
Lai IC, Yang CC, Kuo TB, Shieh KR*: Transcranial magnetic stimulation for auditory hallucination in severe schizophrenia: Partial efficacy and acute elevation of sympathetic modulation. Psychiatry and Clinical Neurosciences 64: 333-335, 2010.
Kuo TB, Lai CT, Hsu FC, Tseng YJ, Li JY, Shieh KR, Tsai SC, Yang CC: Cardiac neural regulation oscillates with the estrous cycle in freely moving female rats: the role of endogenous estrogens. Endocrinology 151: 2613-2621, 2010.
Hsieh MC, Yang SC, Tseng HL, Hwang LL, Chen CT, Shieh KR*: Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long term, high-fat diet-treated mice. International Journal of Obesity 34: 227-239, 2010.
Shaw FZ, Chuang SH, Shieh KR, Wang YJ: Depression- and anxiety-like behaviors of a rat model with absence epileptic discharges. Neuroscience 160: 382-393, 2009.
Harnod T, Yang CCH, Hsin YL, Shieh KR, Wang PJ, Kuo TBJ: Heart rate variability in patients with frontal lobe epilepsy. Seizure 18: 21-25, 2009.
Shieh KR, Yang SC: Effects of estradiol on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript peptide in female rats. Neuroscience 154: 1589-1597, 2008.
Shieh KR, Lee HJ, Yang SC: Different patterns of food consumption and locomotor activity between Taiwanese native rodent, formosan wood mouse (Apodemus semotus), and common laboratory mouse, C57BL/6 (Mus musculus). Chinese Journal of Physiology 51: 129-135, 2008.
Harnod T, Yang CCH, Hsin YL, Shieh KR, Wang PJ, Kuo TBJ: Heart rate variability in children with refractory generalized epilepsy. Seizure 17: 297-301, 2008.
Lai IC, Yang CCH, Kuo TBJ, Wang YC, Shieh KR: Immediate impact of electroconvulsive therapy on cardiac autonomic function in schizophrenia: A preliminary study. Schizophrenia Research 100: 353-355, 2008.
Yang SC, Shieh KR*: Gonadal hormones-mediated effects on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript (CART) peptide in male rats. Neuropharmacology 53: 801-809, 2007.
Yang SC, Shieh KR, Li HY: Cocaine- and amphetamine-regulated transcript (CART) peptide in the nucleus accumbens participates in the regulation of feeding behavior in rats. Neuroscience 133: 841-851, 2005.
Yang SC, Shieh KR*: Differential effects of melanin concentrating hormone on the central dopaminergic neurons induced by the cocaine- and amphetamine-regulated transcript. Journal of Neurochemistry 92: 637-646, 2005.
Shieh KR*, Yang SC, Lu XY, Akil H, Watson SJ: Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain. Journal of Biomedical Science 12: 209-217, 2005.
Yang SC, Shieh KR*: Effects of the cocaine- and amphetamine-regulated transcript peptide on the turnover of tuberoinfundibular dopaminergic neurons and serum prolactin levels: studies using estrogen, melanin concentrating hormone, and melanocortin. Neuropharmacology 47: 1070-1080, 2004.
Wei Q, Lu XY, Liu L, Schafer G, Shieh KR, Burke S, Robinson TE, Watson SJ, Seasholtz AF, Akil H: Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability. Proceedings of the National Academy of Sciences of the United States of America 101: 11851-11856, 2004.
Shieh KR*: Distribution of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain. Neuroscience 118: 831-843, 2003.
Shieh KR*: Effect of the cocaine- and amphetamine-regulated transcript peptide on the turnover of central dopaminergic neurons. Neuropharmacology 44: 940-948, 2003.
Isgor C, Shieh KR, Akil H, Watson SJ: Colocalization of estrogen beta-receptor messenger RNA with orphanin FQ, vasopressin and oxytocin in the rat hypothalamic paraventricular and supraoptic nuclei. Anatomy and Embryology 206: 461-469, 2003. (Shieh KR and Isgor C contributed equally to this work)
Lu XY, Shieh KR, Kabbaj M, Barsh GS, Akil H, Watson SJ: Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake. Endocrinology 143: 3905-3915, 2002.
Shieh KR, Pan JT: Effect of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 280: R705-712, 2001.
Lin JY, Yen SH, Shieh KR, Liang SH, Pan JT: Dopamine and 7-OH-DPAT may act on D3 receptors to inhibit tuberoinfundibular dopaminergic neurons. Brain Research Bulletin 52: 567-572, 2000.
Chu YS, Shieh KR, Pan JT: Stimulatory and entraining effect of melatonin on tuberoinfundibular dopaminergic neuron activity and inhibition on prolactin secretion. Journal of Pineal Research 28: 219-226, 2000.
Shieh KR, Pan JT: Stimulatory role of prolactin on the development of tuberoinfundibular dopaminergic neurones in prepubertal female rats: Studies with cysteamine and somatostatin. Journal of Neuroendocrinology 11: 907-917, 1999.
Lu XY, Gunn TM, Shieh KR, Barsh GS, Akil H, Watson SJ: Distribution of mahogany/attactin messenger RNA in the central nervous system of the rat. FEBS Letters 462: 101-107, 1999.
Shieh KR, Pan JT: Ontogeny of the diurnal rhythm of tuberoinfundibular dopaminergic neuronal activity in peripubertal female rats: possible involvement of cholinergic and opioidergic systems. Neuroendocrinology 68: 395-402, 1998.
Shieh KR, Chu YS, Pan JT: Circadian change of dopaminergic neuron activity: effects of constant light and melatonin. Neuroreport 8: 2283-2287, 1997.
Shieh KR, Pan JT: Nicotinic control of tuberoinfundibular dopaminergic neuron activity and prolactin secretion: diurnal rhythm and involvement of endogenous opioidergic system. Brain Research 756: 266-272, 1997.
Shieh KR, Pan JT: Sexual differences in the diurnal changes of tuberoinfundibular dopaminergic neuron activity in the rat: Role of cholinergic control. Biology of Reproduction 54: 987-992, 1996.
Shieh KR, Pan JT: An endogenous cholinergic rhythm may be involved in the circadian changes of tuberoinfundibular dopaminergic neuron activity in ovariectomized rats treated with or without estrogen. Endocrinology 136: 2383-2388, 1995.
Mai LM, Shieh KR, Pan JT: Circadian changes of serum prolactin levels and tuberoinfundibular dopaminergic neuron activities in ovariectomized rats treated with or without estrogen: the role of suprachiasmatic nuclei. Neuroendocrinology 60: 520-526, 1994.
Wang PK, Cao J, Wang H, Liang L, Zhang J, Lutz BM, Shieh KR, Bekker A, Tao YX: Short-term sleep disturbance-induced stress does not affect basal pain perception, but does delay postsurgical pain recovery. Journal of Pain. In Press.
Yang SC, Chen CL, Yi CH, Liu TT, Shieh KR*: Changes in gene expression patterns of circadian-clock, transient receptor potential vanilloid-1 and nerve growth factor in inflamed human esophagus. Scientific Reports. 5: 13602, 2015.
Tseng HL, Yang SC, Shieh KR*: Hepatic circadian-clock system altered by insulin resistance, diabetes and insulin sensitizer in mice. PLOS One. 10: e0120380, 2015.
Shieh KR, Yang SC, Tseng HL, Yi CH, Liu TT, Chen CL: Evidence for up-regulation of purinergic receptor genes associating with TRPV1 receptors and neurotrophic factors in the inflamed human esophagus. Current Molecular Medicine 14: 1205-1214, 2014.
Yang SC, Tseng HL, Shieh KR*: Circadian-clock system in mouse liver affected by insulin resistance. Chronobiology International 30: 796-810, 2013.
Shieh KR, Yi CH, Liu TT, Tseng HL, Ho HC, Hsieh HT, Chen CL: Evidence for neurotrophic factors associating with TRPV1 gene expression in the inflamed human esophagus. Neurogastroenterology and Motility 9: 971-e252, 2010.
Lai IC, Yang CC, Kuo TB, Shieh KR*: Transcranial magnetic stimulation for auditory hallucination in severe schizophrenia: Partial efficacy and acute elevation of sympathetic modulation. Psychiatry and Clinical Neurosciences 64: 333-335, 2010.
Kuo TB, Lai CT, Hsu FC, Tseng YJ, Li JY, Shieh KR, Tsai SC, Yang CC: Cardiac neural regulation oscillates with the estrous cycle in freely moving female rats: the role of endogenous estrogens. Endocrinology 151: 2613-2621, 2010.
Hsieh MC, Yang SC, Tseng HL, Hwang LL, Chen CT, Shieh KR*: Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long term, high-fat diet-treated mice. International Journal of Obesity 34: 227-239, 2010.
Shaw FZ, Chuang SH, Shieh KR, Wang YJ: Depression- and anxiety-like behaviors of a rat model with absence epileptic discharges. Neuroscience 160: 382-393, 2009.
Harnod T, Yang CCH, Hsin YL, Shieh KR, Wang PJ, Kuo TBJ: Heart rate variability in patients with frontal lobe epilepsy. Seizure 18: 21-25, 2009.
Shieh KR, Yang SC: Effects of estradiol on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript peptide in female rats. Neuroscience 154: 1589-1597, 2008.
Shieh KR, Lee HJ, Yang SC: Different patterns of food consumption and locomotor activity between Taiwanese native rodent, formosan wood mouse (Apodemus semotus), and common laboratory mouse, C57BL/6 (Mus musculus). Chinese Journal of Physiology 51: 129-135, 2008.
Harnod T, Yang CCH, Hsin YL, Shieh KR, Wang PJ, Kuo TBJ: Heart rate variability in children with refractory generalized epilepsy. Seizure 17: 297-301, 2008.
Lai IC, Yang CCH, Kuo TBJ, Wang YC, Shieh KR: Immediate impact of electroconvulsive therapy on cardiac autonomic function in schizophrenia: A preliminary study. Schizophrenia Research 100: 353-355, 2008.
Yang SC, Shieh KR*: Gonadal hormones-mediated effects on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript (CART) peptide in male rats. Neuropharmacology 53: 801-809, 2007.
Yang SC, Shieh KR, Li HY: Cocaine- and amphetamine-regulated transcript (CART) peptide in the nucleus accumbens participates in the regulation of feeding behavior in rats. Neuroscience 133: 841-851, 2005.
Yang SC, Shieh KR*: Differential effects of melanin concentrating hormone on the central dopaminergic neurons induced by the cocaine- and amphetamine-regulated transcript. Journal of Neurochemistry 92: 637-646, 2005.
Shieh KR*, Yang SC, Lu XY, Akil H, Watson SJ: Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain. Journal of Biomedical Science 12: 209-217, 2005.
Yang SC, Shieh KR*: Effects of the cocaine- and amphetamine-regulated transcript peptide on the turnover of tuberoinfundibular dopaminergic neurons and serum prolactin levels: studies using estrogen, melanin concentrating hormone, and melanocortin. Neuropharmacology 47: 1070-1080, 2004.
Wei Q, Lu XY, Liu L, Schafer G, Shieh KR, Burke S, Robinson TE, Watson SJ, Seasholtz AF, Akil H: Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability. Proceedings of the National Academy of Sciences of the United States of America 101: 11851-11856, 2004.
Shieh KR*: Distribution of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain. Neuroscience 118: 831-843, 2003.
Shieh KR*: Effect of the cocaine- and amphetamine-regulated transcript peptide on the turnover of central dopaminergic neurons. Neuropharmacology 44: 940-948, 2003.
Isgor C, Shieh KR, Akil H, Watson SJ: Colocalization of estrogen beta-receptor messenger RNA with orphanin FQ, vasopressin and oxytocin in the rat hypothalamic paraventricular and supraoptic nuclei. Anatomy and Embryology 206: 461-469, 2003. (Shieh KR and Isgor C contributed equally to this work)
Lu XY, Shieh KR, Kabbaj M, Barsh GS, Akil H, Watson SJ: Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake. Endocrinology 143: 3905-3915, 2002.
Shieh KR, Pan JT: Effect of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 280: R705-712, 2001.
Lin JY, Yen SH, Shieh KR, Liang SH, Pan JT: Dopamine and 7-OH-DPAT may act on D3 receptors to inhibit tuberoinfundibular dopaminergic neurons. Brain Research Bulletin 52: 567-572, 2000.
Chu YS, Shieh KR, Pan JT: Stimulatory and entraining effect of melatonin on tuberoinfundibular dopaminergic neuron activity and inhibition on prolactin secretion. Journal of Pineal Research 28: 219-226, 2000.
Shieh KR, Pan JT: Stimulatory role of prolactin on the development of tuberoinfundibular dopaminergic neurones in prepubertal female rats: Studies with cysteamine and somatostatin. Journal of Neuroendocrinology 11: 907-917, 1999.
Lu XY, Gunn TM, Shieh KR, Barsh GS, Akil H, Watson SJ: Distribution of mahogany/attactin messenger RNA in the central nervous system of the rat. FEBS Letters 462: 101-107, 1999.
Shieh KR, Pan JT: Ontogeny of the diurnal rhythm of tuberoinfundibular dopaminergic neuronal activity in peripubertal female rats: possible involvement of cholinergic and opioidergic systems. Neuroendocrinology 68: 395-402, 1998.
Shieh KR, Chu YS, Pan JT: Circadian change of dopaminergic neuron activity: effects of constant light and melatonin. Neuroreport 8: 2283-2287, 1997.
Shieh KR, Pan JT: Nicotinic control of tuberoinfundibular dopaminergic neuron activity and prolactin secretion: diurnal rhythm and involvement of endogenous opioidergic system. Brain Research 756: 266-272, 1997.
Shieh KR, Pan JT: Sexual differences in the diurnal changes of tuberoinfundibular dopaminergic neuron activity in the rat: Role of cholinergic control. Biology of Reproduction 54: 987-992, 1996.
Shieh KR, Pan JT: An endogenous cholinergic rhythm may be involved in the circadian changes of tuberoinfundibular dopaminergic neuron activity in ovariectomized rats treated with or without estrogen. Endocrinology 136: 2383-2388, 1995.
Mai LM, Shieh KR, Pan JT: Circadian changes of serum prolactin levels and tuberoinfundibular dopaminergic neuron activities in ovariectomized rats treated with or without estrogen: the role of suprachiasmatic nuclei. Neuroendocrinology 60: 520-526, 1994.